Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00263) | ||||||
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| BTS Name |
Transmembrane glycoprotein NMB
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| Synonyms |
Hematopoietic growth factor inducible neurokinin-1 type
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| BTS Type |
Protein
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| Family |
PMEL/NMB family
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| Gene Name |
GPNMB
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| Organism |
Homo sapiens (Human)
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| Function |
Could be a melanogenic enzyme.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MECLYYFLGFLLLAARLPLDAAKRFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYP
VWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNC RNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTL GQYFQKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFV TMFQKNDRNSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVN HTYVLNGTFSLNLTVKAAAPGPCPPPPPPPRPSKPTPSLATTLKSYDSNTPGPAGDNPLE LSRIPDENCQINRYGHFQATITIVEGILEVNIIQMTDVLMPVPWPESSLIDFVVTCQGSI PTEVCTIISDPTCEITQNTVCSPVDVDEMCLLTVRRTFNGSGTYCVNLTLGDDTSLALTS TLISVPDRDPASPLRMANSALISVGCLAIFVTVISLLVYKKHKEYNPIENSPGNVVRSKG LSVFLNRAKAVFFPGNQEKDPLLKNQEFKGVS |
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| Sequence Length |
572
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| scFv anti-GPNMB 902V | Research | Binder | Kd: 0.77 nM | Glioma [ICD-11: 2A00.0] | [1] | |
| scFv anti-GPNMB F6V | Research | Binder | Kd: 0.3 nM | Glioma [ICD-11: 2A00.0] | [1] | |
| scFv anti-GPNMB G49 | Research | Binder | Kd: 8.4 nM | Glioma [ICD-11: 2A00.0] | [1] | |
| scFv anti-GPNMB L22 | Research | Binder | Kd: 3.7 nM | Glioma [ICD-11: 2A00.0] | [1] | |