General Information of Synthetic Binding Protein (SBP) (ID: SBP001552)
SBP Name
Fab anti-TNF-alpha G10
Synonyms
Fab G10
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Phage display
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS034
Scaffold Info
[1]
Scaffold Name Fab
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Tumor necrosis factor
BTS Info
Inhibitor Research tool N.A. China Pharmaceutical University [1]
References
1 Optimization and modification of anti-rhTNF- single chain variable fragment antibody: effective in vitro affinity maturation and functional expression of chimeric Fab. Biomed Pharmacother. 2013 Jun;67(5):437-44.