Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP001546) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Fab anti-gp120-CD4 complex clone X5
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| Synonyms |
Fab X5
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| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Selection Method | Phage display | |||||
| Highest Status | Research | |||||
| PDB ID | 1RHH | |||||
| SBP Sequence |
>Heavy Chain
EVQLLEQSGAEVKKPGSSVQVSCKASGGTFSMYGFNWVRQAPGHGLEWMGGIIPIFGTSN YAQKFRGRVTFTADQATSTAYMELTNLRSDDTAVYYCARDFGPDWEDGDSYDGSGRGFFD FWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTS >Light Chain ELVLTQSPGTLSLSAGERATLSCRASQSVSSGSLAWYQQKPGQAPRLLIYGASTRATGIP DRFSGSGSGTDFTLTIGRLEPEDLAVYYCQQYGTSPYTFGQGTKLEIKRTVAAPSVFIFP PSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSRDSTYSLGSTL TLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
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| 3D Structure | ||||||
| Experimentally Validated Structure | ||||||
| Click to Save PDB File | ||||||
| Protein Scaffold Information of This SBP | ||||||
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| Scaffold ID | PS034 | [1] , [2] | ||||
| Scaffold Name | Fab | |||||
| Scaffold Class | Antibody fragment | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
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| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| HIV envelope glycoprotein gp120-CD4 complex | Binder | Human immunodeficiency virus infection (HIV infection) [ICD-11: 1C62.Z] | Kd: 0.09 nM | The Scripps Research Institute | [1] , [2] | |
| References |
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