General Information of Binding Target of SBP (BTS) (ID: ST00430)
BTS Name
HIV envelope glycoprotein gp120-CD4 complex
Synonyms
gp120-CD4 complex
BTS Type
Protein
Organism
Human immunodeficiency virus (HIV)
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Fab anti-gp120-CD4 complex clone X5 Research Binder Kd: 0.09 nM Human immunodeficiency virus infection (HIV infection) [ICD-11: 1C62.Z]
SBP Info
[1], [2]
References
1 Improved breadth and potency of an HIV-1-neutralizing human single-chain antibody by random mutagenesis and sequential antigen panning. J Mol Biol. 2004 Jan 2;335(1):209-19.
2 Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexes. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6913-8.