General Information of Synthetic Binding Protein (SBP) (ID: SBP001518)
SBP Name
Fab anti-SEB
Synonyms
Anti-SEB Fab
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Phage display
Highest Status Research
SBP Sequence
>VH Chain
SGAELVKPGASVKLSCTASGFNIKDTYMHWVKQRPEQGLEWIGRIDPANGNTKYDPKFQG
KATITADTSSNTAYLQLSSLTSEDTAVYYCAFYGNFEDYAVDYWGQGT
>VL Chain
DVVMSQSPSSLAVSVGEKVTMSCKSSQSLLYSSNQKNYLAWYQQKPGQSPKLLIYWASTR
ESGVPDRFTGSGSGTDFTLTISSVKAEDLAVYYCQQYYSYPYTFGGGTKLEIKRADAA
Template Name scFv
Protein Scaffold Information of This SBP
Scaffold ID PS034
Scaffold Info
[1]
Scaffold Name Fab
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Enterotoxin type B
BTS Info
Binder Research tool Kd: 4.1 nM National Research Institute of Police Science [1]
References
1 Generation of Fab fragment-like molecular recognition proteins against staphylococcal enterotoxin B by phage display technology. Clin Vaccine Immunol. 2010 Nov;17(11):1708-17.