Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP001506) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
DARPin anti-ERBB2 H10-2-A2
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| Synonyms |
DARPin H10-2-A2
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| Molecular Weight | 13.2 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Escherichia coli | |||||
| Selection Method | Ribosome display | |||||
| Highest Status | Research | |||||
| Sequence Length | 123 | |||||
| SBP Sequence |
>DARPin anti-ERBB2 H10-2-A2
DLGKKLLEAARAGQDDEVRILMAKGADVNALDWRGFTPLYLAVASGHLEIVEVLLKNGAD VNADDAIGFTSLHLAAYLGHLEIVEVLLKHGADVNAQDKFGKTAFDISIDNGNEDLAEIL QKL |
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| 3D Structure | ||||||
| Computationally Modelled Structure | ||||||
| Click to Save PDB File | ||||||
| Template Name | N2C | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS027 | [1] | ||||
| Scaffold Name | DARPin | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Alpha-Helices + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
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| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Receptor tyrosine-protein kinase erbB-2 | Binder | Tools for detecting Her5 in human carcinoma extracts | Kd: 3.5 nM | New York University School of Medicine | [1] | |