General Information of Synthetic Binding Protein (SBP) (ID: SBP001492)
SBP Name
DARPin anti-TNF-R2 clone 18
Synonyms
DARPin 18
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS027
Scaffold Info
[1]
Scaffold Name DARPin
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Tumor necrosis factor receptor superfamily member 1B
BTS Info
Activator Tools for enhancing IL2-induced T regs proliferation N.A. University of Cambridge [1]
References
1 TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-B pathway. Sci Rep. 2018 Aug 13;8(1):12079.