Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP001474)
SBP Name	DARPin anti-VEGFR-2 D23b
Synonyms	DARPin D23b
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System	Escherichia coli
Selection Method	Ribosome display
Highest Status	Research

Protein Scaffold Information of This SBP
Scaffold ID	PS027 Scaffold Info					[1] , [2]
Scaffold Name	DARPin
Scaffold Class	Non-Antibody
Fold Type	Alpha-Helices + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
Vascular endothelial growth factor receptor 2	BTS Info	Inhibitor	Diagnostic reagent	Kd: 0.01 nM	Paul Scherrer Institute	[1] , [2]

References

1	Targeting extracellular domains D4 and D7 of vascular endothelial growth factor receptor 2 reveals allosteric receptor regulatory sites. Mol Cell Biol. 2012 Oct;32(19):3802-13.
2	High-affinity binders selected from designed ankyrin repeat protein libraries. Nat Biotechnol. 2004 May;22(5):575-82.