Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP001422) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
DARPin anti-KRas K13
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| Synonyms |
DARPin K13
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| Molecular Weight | 16.8 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Escherichia coli BL21 (DE3) | |||||
| Selection Method | Phage display | |||||
| Highest Status | Research | |||||
| PDB ID | 6H46 | |||||
| Sequence Length | 156 | |||||
| SBP Sequence |
>DARPin anti-KRas K13
MDLGKKLLEAARAGQDDEVRILMANGADVNASDRWGWTPLHLAAWWGHLEIVEVLLKHGA DVNAADLHGQTPLHLAAMVGHLEIVEVLLKYGADVNAKDTMGATPLHLAAQSGHLEIVEV LLKNGADVNAQDKFGKTAFDISIDNGNEDLAEILQK |
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| 3D Structure | ||||||
| Experimentally Validated Structure | ||||||
| Click to Save PDB File | ||||||
| Template Name | AR module | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS027 | [1] | ||||
| Scaffold Name | DARPin | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Alpha-Helices + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| GTPase KRas | Inhibitor | Cancers [ICD-11: 2D4Z] | Kd: 30 nM | University of Oxford | [1] | |