Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP001071)
SBP Name
Nanobody anti-KDELR2 clone 37
Synonyms
Syb37
Molecular Weight 13.6 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method Phage display and Ribosome display
Highest Status Research
PDB ID 6I6J
Sequence Length 121
SBP Sequence
>Nanobody anti-KDELR2 clone 37
QVQLVESGGGLVQAGGSLRLSCAASGFPVKRWSMTWYRQAPGKEREWVAAIRSAGHWTHY
ADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCNVKDEGDFSYWYDYWGQGTQVTVS
A
3D Structure
Experimentally Validated Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS048
Scaffold Info
[1] , [2]
Scaffold Name Nanobody
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
ER lumen protein-retaining receptor 2
BTS Info
Binder Tools for the conformational trapping of membrane proteins N.A. University of Oxford [1] , [2]
References
1 Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor. Science. 2019 Mar 8;363(6431):1103-1107.
2 Synthetic single domain antibodies for the conformational trapping of membrane proteins. Elife. 2018 May 24;7:e34317.