Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00231)
BTS Name
ER lumen protein-retaining receptor 2
Synonyms
KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2
BTS Type
Protein
Family
ERD2 family
Gene Name
KDELR2
Organism
Gallus gallus (Chicken)
Function
Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4
UniProt ID
Q5ZKX9
UniProt Entry
ERD22_CHICK
PFam
PF00810
Gene ID
771927
Sequence
MNIFRLTGDLSHLAAIIILLLKIWKSRSCAGISGKSQLLFALVFTTRYLDLFTSFISLYN
TSMKLIYIACSYATVYLIYMKFKATYDGNHDTFRVEFLIVPVGGLSFLVNHDFSPLEILW
TFSIYLESVAILPQLFMISKTGEAETITTHYLFFLGLYRALYLVNWIWRYYFEGFFDLIA
VVAGVVQTVLYCDFFYLYVTKVLKGKKLSLPA
Sequence Length
212
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Nanobody anti-KDELR2 clone 37 Research Binder N.A. Tools for the conformational trapping of membrane proteins
SBP Info
 		[1], [2]
References
1 Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor. Science. 2019 Mar 8;363(6431):1103-1107.
2 Synthetic single domain antibodies for the conformational trapping of membrane proteins. Elife. 2018 May 24;7:e34317.