Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP001035) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Nanobody anti-AT1R AT120
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| Synonyms |
Nanobody AT120
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| Molecular Weight | 12.6 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Escherichia coli BL21 (DE3) | |||||
| Selection Method | Saccharomyces cerevisiae yeast display | |||||
| Highest Status | Research | |||||
| Sequence Length | 116 | |||||
| SBP Sequence |
>Nanobody anti-AT1R AT120
QVQLQESGLVQAGGSLRLSCAASGNIFGGVGMGWYRQAPGKEREFVAGINNGGTTNYADS VKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAVVRPSFDYHVYWGQGTQVTVSS |
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| 3D Structure | ||||||
| Computationally Modelled Structure | ||||||
| Click to Save PDB File | ||||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS048 | [1] | ||||
| Scaffold Name | Nanobody | |||||
| Scaffold Class | Antibody fragment | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Type-1 angiotensin II receptor | Antagonist | Hypertensive disorders [ICD-11: BA00.Z] | N.A. | Harvard Medical School | [1] | |