Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00215) | ||||||
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| BTS Name |
Type-1 angiotensin II receptor
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| Synonyms |
AT1AR; AT1BR; Angiotensin II type-1 receptor; AT1
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| BTS Type |
Protein
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| Family |
G-protein coupled receptor 1 family
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| Gene Name |
AGTR1
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| Organism |
Homo sapiens (Human)
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| Function |
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.; (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE |
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| Sequence Length |
359
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Nanobody anti-AT1R AT110i1 | Research | Activator | EC50: 18.5nM | Research tool | [1] | |
| Nanobody anti-AT1R AT110i1le | Research | Inhibitor | Kd: 10.8 nM | Research tool | [2] | |
| Nanobody anti-AT1R AT118 | Research | Antagonist | N.A. | Hypertensive disorders [ICD-11: BA00.Z] | [3] | |
| Nanobody anti-AT1R AT118i4 | Research | Antagonist | N.A. | Hypertensive disorders [ICD-11: BA00.Z] | [3] | |
| Nanobody anti-AT1R AT120 | Research | Antagonist | N.A. | Hypertensive disorders [ICD-11: BA00.Z] | [3] | |
| References |
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