General Information of Synthetic Binding Protein (SBP) (ID: SBP001031)
SBP Name
Nanobody anti-SARS-CoV-2 clone 18
Synonyms
Nb18
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method Yeast display
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS048
Scaffold Info
[1]
Scaffold Name Nanobody
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Spike glycoprotein
BTS Info
Inhibitor SARS-CoV-2 infection (COVID-19) [ICD-11: XN109] Kd: 45 nM University of California at San Francisco [1]
References
1 An ultra-high affinity synthetic nanobody blocks SARS-CoV-2 infection by locking Spike into an inactive conformation. bioRxiv. 2020 Aug 10;2020.08.08.238469.