General Information of Synthetic Binding Protein (SBP) (ID: SBP001027)
SBP Name
Nanobody anti-SARS-CoV-2 trivalent matured clone 6
Synonyms
Trivalent matured Nb6; mNb6-tri
Thermal Denaturation TEMP 61.4 ℃
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method Yeast display
Highest Status Research
Template Name mNb6
Protein Scaffold Information of This SBP
Scaffold ID PS048
Scaffold Info
[1]
Scaffold Name Nanobody
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Spike glycoprotein
BTS Info
Inhibitor SARS-CoV-2 infection (COVID-19) [ICD-11: XN109] N.A. University of California at San Francisco [1]
References
1 An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science. 2020 Dec 18;370(6523):1473-1479.