Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP001009)
SBP Name	Diabody anti-ERBB1/CD3 hEx3
Synonyms	Diabody hEx3
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System	Escherichia coli BL21 (DE3)
Highest Status	Research

Protein Scaffold Information of This SBP
Scaffold ID	PS031 Scaffold Info					[1] , [2]
Scaffold Name	Diabody
Scaffold Class	Antibody fragment
Fold Type	Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
T-cell surface glycoprotein CD3	BTS Info	Binder	Imaging agent for patients with cancer; Cancers [ICD-11: 2D4Z]	N.A.	Tohoku University	[1] , [2]
Epidermal growth factor receptor	BTS Info	Binder	Imaging agent for patients with cancer; Cancers [ICD-11: 2D4Z]	N.A.	Tohoku University	[1] , [2]

References

1	Humanization of the bispecific epidermal growth factor receptor x CD3 diabody and its efficacy as a potential clinical reagent. Clin Cancer Res. 2006 Jul 1;12(13):4036-42.
2	Domain order of a bispecific diabody dramatically enhances its antitumor activity beyond structural format conversion: the case of the hEx3 diabody. Protein Eng Des Sel. 2013 May;26(5):359-67.