General Information of Synthetic Binding Protein (SBP) (ID: SBP000887)
SBP Name
Gp2-based binder anti-HEWL GalphaLysA(0.3.3)
Synonyms
Gp2-based binder GalphaLysA(0.3.3)
Molecular Weight 7.3 kDa
Thermal Denaturation TEMP 65 ℃
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method Yeast display
Highest Status Research
Sequence Length 64
SBP Sequence
>Gp2-based binder anti-HEWL GalphaLysA(0.3.3)
MSNVNTGSLSVDNKKFWATVFSYGNLFEVPIYAETLDEALELAEWQYSGAYEYVTRVRPC
VAPK
3D Structure
Computationally Modelled Structure
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Template Name Gp2 domain
Protein Scaffold Information of This SBP
Scaffold ID PS038
Scaffold Info
[1]
Scaffold Name Gp2-based binder
Scaffold Class Non-Antibody
Fold Type One Alpha-Helix + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Hen egg-white lysozyme
BTS Info
Binder Research tool Kd: 0.9 nM University of Minnesota [1]
References
1 A 45-Amino-Acid Scaffold Mined from the PDB for High-Affinity Ligand Engineering. Chem Biol. 2015 Jul 23;22(7):946-56.