General Information of Synthetic Binding Protein (SBP) (ID: SBP000806)
SBP Name
WW domain anti-VEGFR-2 clone B1
Synonyms
WW domain-based binder B1
Molecular Weight 4.5 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method CIS display
Highest Status Research
Sequence Length 38
SBP Sequence
>WW domain anti-VEGFR-2 clone B1
MADEEKLPPGWYKMWSSPGRVLYVNDITHAHRWERPSG
3D Structure
Computationally Modelled Structure
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Template Name Peptide
Protein Scaffold Information of This SBP
Scaffold ID PS067
Scaffold Info
[1]
Scaffold Name WW domain
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Vascular endothelial growth factor receptor 2
BTS Info
Binder Research tool Kd: 44 nM Isogenica Ltd [1]
References
1 Selection of a high-affinity WW domain against the extracellular region of VEGF receptor isoform-2 from a combinatorial library using CIS display. Protein Eng Des Sel. 2013 Apr;26(4):307-15.