Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP000780) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Designed TPR protein anti-hsp90 D334K mutant
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| Synonyms |
Designed TPR protein D334K mutant
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| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Escherichia coli BL21 (DE3) | |||||
| Highest Status | Research | |||||
| Template Name | TPR2A domain | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS030 | [1] | ||||
| Scaffold Name | Designed TPR protein | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Alpha-Helices + Beta-Turns | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Heat shock protein HSP 90-beta | Binder | Cancers [ICD-11: 2D4Z] | Kd: 250 nM | Yale University | [1] | |