General Information of Synthetic Binding Protein (SBP) (ID: SBP000727)
SBP Name
VNAR anti-TOM70 12F-11
Synonyms
VNAR 12F-11
Molecular Weight 11.7 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Phage display
Highest Status Research
Sequence Length 103
SBP Sequence
>VNAR anti-TOM70 12F-11
TRVDQTPRTATKETGESLTINCVLRDTSFPLNKTYWYRRFSSTNEQHIPIGGRYVETVNK
RSKSFSLRISDLRVEDSGTYRCGAYNLSGIYYSWGAGTALTVK
3D Structure
Computationally Modelled Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS065
Scaffold Info
[1]
Scaffold Name vNAR
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Mitochondrial import receptor subunit TOM70
BTS Info
Binder Research tool Kd: 2 nM CSIRO Health Sciences and Nutrition [1]
References
1 Isolation and characterization of an IgNAR variable domain specific for the human mitochondrial translocase receptor Tom70. Eur J Biochem. 2003 Sep;270(17):3543-54.