Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000560)
SBP Name	Cyclotide anti-NRP1/NRP2 N2.1C
Synonyms	Cyclotide N2.1C
Molecular Weight	3.2 kDa
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method	Bacteria display
Highest Status	Research
Sequence Length	29

Protein Scaffold Information of This SBP
Scaffold ID	PS023 Scaffold Info					[1]
Scaffold Name	Cyclotide
Scaffold Class	Non-Antibody
Fold Type	Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
Neuropilin-2	BTS Info	Antagonist	Cancers [ICD-11: 2D4Z]	N.A.	University of California	[1]
Neuropilin-1	BTS Info	Antagonist	Cancers [ICD-11: 2D4Z]	Kd: 51 nM	University of California	[1]

References

1

Design of a cyclotide antagonist of neuropilin-1 and -2 that potently inhibits endothelial cell migration. ACS Chem Biol. 2013;8(6):1147-54.