General Information of Synthetic Binding Protein (SBP) (ID: SBP000535)
SBP Name
Knottin anti-Mast cell tryptase beta oMCoEETI(KKV)
Synonyms
Knottin oMCoEETI(KKV)
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Sequence Length 34
SBP Sequence
>Knottin anti-Mast cell tryptase beta oMCoEETI(KKV)
SVCPKILKKCRRDSDCLAGCVCGPNGFCGAKKVX
Sequence Description Cys I and Cys IV form disulfide bonds; Cys II and Cys V form disulfide bonds; Cys III and Cys VI form disulfide bonds; oMCoEETI(KKV) is a linear peptide; X represents homoserine lactone.
3D Structure
Computationally Modelled Structure
Click to Save PDB File
Template Name MCoEETI-II
Template Sequence Description Cys I and Cys IV form disulfide bonds; Cys II and Cys V form disulfide bonds; Cys III and Cys VI form disulfide bonds.
Protein Scaffold Information of This SBP
Scaffold ID PS042
Scaffold Info
[1]
Scaffold Name Knottin
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Mast cell tryptase beta III
BTS Info
Inhibitor Allergic asthma [ICD-11: CA23.02]; Inflammatory disorders [ICD-11: 4A6Z] N.A. Ludwig-Maximilians-University Munich [1]
References
1 Engineered cystine knot miniproteins as potent inhibitors of human mast cell tryptase beta. J Mol Biol. 2010 Jan 8;395(1):167-75.