General Information of Synthetic Binding Protein (SBP) (ID: SBP000425)
SBP Name
Kunitz domain anti-PKK EPI-K503
Synonyms
Kunitz domain anti-PKK EPI-K503
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Saccharomyces cerevisiae
Selection Method Phage display
Highest Status Research
Template Name LACI-D1
Protein Scaffold Information of This SBP
Scaffold ID PS043
Scaffold Info
[1]
Scaffold Name Kunitz domain
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Plasma kallikrein
BTS Info
Inhibitor Research tool Kd: 0.04 nM Protein Engineering Corporation [1]
References
1 Iterative optimization of high-affinity protease inhibitors using phage display. 2. Plasma kallikrein and thrombin. Biochemistry. 1996 Jun 18;35(24):8058-67.