Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP000424) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Kunitz domain anti-PKK/FXIa KALI-DY
|
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| Synonyms |
Kunitz domain anti-PKK/FXIa KALI-DY
|
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| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Escherichia coli 27C7 | |||||
| Selection Method | Phage display | |||||
| Highest Status | Research | |||||
| Template Name | APPI | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS043 | [1] | ||||
| Scaffold Name | Kunitz domain | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Alpha-Helices + Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Plasma kallikrein | Inhibitor | Tools as inhibitors of human plasma kallikrein | Kd: 0.015 nM | Genentech Inc | [1] | |
| Coagulation factor XI | Inhibitor | Tools as inhibitors of human plasma kallikrein | Kd: 8.2 nM | Genentech Inc | [1] | |