General Information of Synthetic Binding Protein (SBP) (ID: SBP000409)
SBP Name
Repebody anti-ERBB1 rAC1
Synonyms
Repebody rAC1
Molecular Weight 28.3 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
PDB ID 4UIP
Sequence Length 251
SBP Sequence
>Repebody anti-ERBB1 rAC1
METITVSTPIKQIFPDDAFAETIKANLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGI
QYLPNVRYLALGGNKLHDISALKELTNLTYLMLHYNQLQILPNGVFDKLTNLKELYLSEN
QLQSLPDGVFDKLTNLTELDLARNQLQSLPKGVFDKLTQLKDLRLYQNQLKSVPDGVFDR
LTSLQYIWLHDNPWDCTCPGIRYLSEWINKHSGVVRNSAGSVAPDSAKCSGSGKPVRSII
CPTLEHHHHHH
3D Structure
Experimentally Validated Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS055
Scaffold Info
[1]
Scaffold Name Repebody
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Epidermal growth factor receptor
BTS Info
Binder Research tool N.A. Korea Advanced Institute of Science and Technology (KAIST) [1]
References
1 Enzymatic prenylation and oxime ligation for the synthesis of stable and homogeneous protein-drug conjugates for targeted therapy. Angew Chem Int Ed Engl. 2015 Oct 5;54(41):12020-4. doi: 10.1002/anie.201505964. Epub 2015 Aug 28.