Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000400)
SBP Name
Repebody anti-IL-6 F11
Synonyms
Repebody F11
Molecular Weight 29.7 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Phage display
Highest Status Research
Sequence Length 266
SBP Sequence
>Repebody anti-IL-6 F11
ETITVSTPIKQIFPDDAFAETIKANLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGIQ
YLPNVRYLALGGNKLHDISALKELTNLTYLTLEPNQLQSLPNGVFDKLTNLKELSLWMNQ
LQSLPDGVFDKLTNLTYLNLAHNQLQSLPKGVFDKLTNLTELDLSYNQLQSLPEGVFDKL
TQLKDLRLYQNQLKSVPDGVFDRLTSLQYIWLHDNPWDCTCPGIRYLSEWINKHSGVVRN
SAGSVAPDSAKCSGSGKPVRSIICPT
3D Structure
Computationally Modelled Structure
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Template Name Repebody
Protein Scaffold Information of This SBP
Scaffold ID PS055
Scaffold Info
[1]
Scaffold Name Repebody
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Interleukin-6
BTS Info
Binder Research tool Kd: 117 nM Korea Advanced Institute of Science and Technology (KAIST) [1]
References
1 Design of a binding scaffold based on variable lymphocyte receptors of jawless vertebrates by module engineering. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3299-304.