Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP000395) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Repebody anti-IL-6 r-D3E8C4
|
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| Synonyms |
Repebody r-D3E8C4
|
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| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Selection Method | Phage display | |||||
| Highest Status | Research | |||||
| SBP Sequence |
>Module 2
K102, T104, V106, S107 >Module 3 T126, E128, P129 >Module 4 Q150, W152, A153 >Module 5 Y172, N174, A176, H177 |
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| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS055 | [1] | ||||
| Scaffold Name | Repebody | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Alpha-Helices + Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Interleukin-6 | Blocker | Non-small cell lung cancer [ICD-11: 2C25.Y] | Kd: 0.4 nM | Korea Advanced Institute of Science and Technology (KAIST) | [1] | |