Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000394)
SBP Name
Repebody anti-IL-6 r-D3E8
Synonyms
Repebody r-D3E8
Molecular Weight 29.2 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method Phage display
Highest Status Research
PDB ID 4J4L
Sequence Length 261
SBP Sequence
>Repebody anti-IL-6 r-D3E8
PIKQIFPDDAFAETIKANLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGIQYLPNVRY
LALGGNKLHDISALKELTNLTYLTLEPNQLQSLPNGVFDKLTNLKELQLWANQLQSLPDG
VFDKLTNLTYLNLAFNQLQSLPKGVFDKLTNLTELDLSYNQLQSLPKGVFDKLTQLKDLR
LYQNQLKSVPDGVFDRLTSLQYIWLHDNPWDCTCPGIRYLSEWINKHSGVVRNSAGSVAP
DSAKCSGSGKPVRSIICPTLE
3D Structure
Experimentally Validated Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS055
Scaffold Info
[1]
Scaffold Name Repebody
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Interleukin-6
BTS Info
Blocker Non-small cell lung cancer [ICD-11: 2C25.Y] Kd: 2.5 nM Korea Advanced Institute of Science and Technology (KAIST) [1]
References
1 A high-affinity protein binder that blocks the IL-6/STAT3 signaling pathway effectively suppresses non-small cell lung cancer. Mol Ther. 2014 Jul;22(7):1254-1265.