General Information of Synthetic Binding Protein (SBP) (ID: SBP000285)
SBP Name
Macrocyclic peptide anti-EpCAM Epi-3
Synonyms
Macrocyclic peptide Epi-3
Molecular Weight 2.2 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System FIT system
Selection Method mRNA display
Highest Status Research
Sequence Length 23
SBP Sequence
>Macrocyclic peptide anti-EpCAM Epi-3
[d-Trp]SRIALRLGLICAAAAAAATGGG
Sequence Description Ac and Cys form a bridge.
Protein Scaffold Information of This SBP
Scaffold ID PS044
Scaffold Info
[1]
Scaffold Name Macrocyclic peptide
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Epithelial cell adhesion molecule
BTS Info
Binder Tools as fluorescent imaging probe Kd: 1.6 nM The University of Tokyo [1]
References
1 A Fluorescent Imaging Probe Based on a Macrocyclic Scaffold That Binds to Cellular EpCAM. J Mol Evol. 2015 Dec;81(5-6):210-7.