General Information of Synthetic Binding Protein (SBP) (ID: SBP000203)
SBP Name
Peptide aptamer anti-ERBB2 AII-7
Synonyms
Peptide aptamer AII-7
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS051
Scaffold Info
[1] , [2]
Scaffold Name Peptide aptamer
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Receptor tyrosine-protein kinase erbB-2
BTS Info
Binder Breast cancer [ICD-11: 2C6Z] N.A. Georg-Speyer-Haus, Institute for Biomedical Research [1] , [2]
References
1 Peptide aptamers with binding specificity for the intracellular domain of the ErbB2 receptor interfere with AKT signaling and sensitize breast cancer cells to Taxol. Mol Cancer Res. 2006 Dec;4(12):983-98.
2 Peptide aptamers with biological and therapeutic applications. Curr Med Chem. 2011;18(27):4215-22.