Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000201)
SBP Name
Peptide aptamer anti-Tgat-GEF TRIP(E32G)
Synonyms
Peptide aptamer GEF TRIP(E32G)
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS051
Scaffold Info
[1] , [1]
Scaffold Name Peptide aptamer
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Rho guanine nucleotide exchange factor 25
BTS Info
Inhibitor Tumors [ICD-11: XH1N44] N.A. University of Montpellier [1] , [1]
References
1 Aptamer-derived peptides as potent inhibitors of the oncogenic RhoGEF Tgat. Chem Biol. 2009 Apr 24;16(4):391-400.