General Information of Synthetic Binding Protein (SBP) (ID: SBP000199)
SBP Name
Peptide aptamer anti-Id clone 10
Synonyms
PA10
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Bacteria
Selection Method Yeast two-hybrid screen
Highest Status Research
SBP Sequence
>Inserted sequence
VGCGSVASSFVSCCAFWACGGSVQNDRPDSG
Template Name Thioredoxin (TrxA)
Protein Scaffold Information of This SBP
Scaffold ID PS051
Scaffold Info
[1] , [2]
Scaffold Name Peptide aptamer
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Inhibitor of differentiation or DNA binding protein
BTS Info
Binder Breast cancer [ICD-11: 2C6Z] N.A. German Cancer Research Center [1] , [2]
References
1 Targeting Id1 and Id3 by a specific peptide aptamer induces E-box promoter activity, cell cycle arrest, and apoptosis in breast cancer cells. Breast Cancer Res Treat. 2010 Dec;124(3):623-33
2 Peptide aptamers with biological and therapeutic applications. Curr Med Chem. 2011;18(27):4215-22.