General Information of Synthetic Binding Protein (SBP) (ID: SBP000195)
SBP Name
Peptide aptamer anti-HPV16 E61-1
Synonyms
Peptide aptamer E6 E61-1
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
SBP Sequence
>Inserted sequence
GALVHKLFSQTSGSCLVCIS
Template Name Thioredoxin (TrxA)
Protein Scaffold Information of This SBP
Scaffold ID PS051
Scaffold Info
[1]
Scaffold Name Peptide aptamer
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Protein E6
BTS Info
Inhibitor Human papillomavirus infection 16 [ICD-11: XN2NK] N.A. Institute of Biochemistry, Faculty of Medicine, University of Cologne [1]
References
1 Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6693-7.