Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000194)
SBP Name
Peptide aptamer anti-ERBB1 KDI1
Synonyms
Peptide aptamer KDI1
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli BL21 (DE3)
Selection Method Yeast two-hybrid screen
Highest Status Research
SBP Sequence
>Inserted sequence
VFGVSWVVGFWCQMHRRLVC
Template Name Thioredoxin (TrxA)
Protein Scaffold Information of This SBP
Scaffold ID PS051
Scaffold Info
[1] , [2]
Scaffold Name Peptide aptamer
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Epidermal growth factor receptor
BTS Info
Blocker Tumors [ICD-11: XH1N44] N.A. Georg Speyer Haus, Institute for Biomedical Research [1] , [2]
References
1 Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells. J Biol Chem. 2003 Sep 26;278(39):37610-21.
2 Peptide aptamers with biological and therapeutic applications. Curr Med Chem. 2011;18(27):4215-22.