Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000183)
SBP Name	Peptide aptamer anti-Smad4 TrxLef1D
Synonyms	Peptide aptamer TrxLef1D
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status	Research

Protein Scaffold Information of This SBP
Scaffold ID	PS051 Scaffold Info					[1] , [2]
Scaffold Name	Peptide aptamer
Scaffold Class	Non-Antibody
Fold Type	Alpha-Helices + Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
Mothers against decapentaplegic homolog 4	BTS Info	Inhibitor	Tools for protein function modulation	N.A.	McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin	[1] , [2]

References

1	Smad4 cooperates with lymphoid enhancer-binding factor 1/T cell-specific factor to increase c-myc expression in the absence of TGF-beta signaling. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18580-5.
2	Peptide aptamers with biological and therapeutic applications. Curr Med Chem. 2011;18(27):4215-22.