Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000180)
SBP Name	Peptide aptamer anti-TSC2 Phi1
Synonyms	Peptide aptamer Phi1
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status	Research

Protein Scaffold Information of This SBP
Scaffold ID	PS051 Scaffold Info					[1] , [2]
Scaffold Name	Peptide aptamer
Scaffold Class	Non-Antibody
Fold Type	Alpha-Helices + Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
Tuberin	BTS Info	Binder	Tools for protein function modulation	N.A.	University of Edinburgh	[1] , [2]

References

1	Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling. J Biol Chem. 2009 Jan 2;284(1):334-344.
2	Peptide aptamers with biological and therapeutic applications. Curr Med Chem. 2011;18(27):4215-22.