Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000173)
SBP Name
Peptide aptamer anti-Smad Trx-xFoxHlb
Synonyms
Peptide aptamer Trx-xFoxHlb
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS051
Scaffold Info
[1] , [2]
Scaffold Name Peptide aptamer
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Mothers against decapentaplegic homolog 4
BTS Info
Inhibitor Tools for protein function modulation N.A. University of Wisconsin-Madison [1] , [2]
References
1 Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP. Oncogene. 2005 Jun 2;24(24):3864-74.
2 Peptide aptamers with biological and therapeutic applications. Curr Med Chem. 2011;18(27):4215-22.