Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000172)
SBP Name
Peptide aptamer anti-Bcl-6 Apt48
Synonyms
Peptide aptamer Apt48
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
SBP Sequence
>Variable region
GPHGPRDWCLFGGP
3D Structure
Computationally Modelled Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS051
Scaffold Info
[1] , [2]
Scaffold Name Peptide aptamer
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
B-cell lymphoma 6 protein homolog
BTS Info
Antagonist Tools for protein function modulation N.A. Hutchison/MRC Research Centre [1] , [2]
References
1 A peptide aptamer to antagonize BCL-6 function. Oncogene. 2006 Apr 6;25(15):2223-33.
2 Peptide aptamers with biological and therapeutic applications. Curr Med Chem. 2011;18(27):4215-22.