Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000154)
SBP Name	DART anti-GPA33/CD3 MGD007
Synonyms	DART MGD007
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status	Research

Protein Scaffold Information of This SBP
Scaffold ID	PS028 Scaffold Info					[1]
Scaffold Name	DART
Scaffold Class	Antibody fragment
Fold Type	Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
T-cell surface glycoprotein CD3	BTS Info	Binder	Metastatic colorectal cancer [ICD-11: 2B91.Z]	N.A.	MacroGenics	[1]
Cell surface A33 antigen	BTS Info	Binder	Metastatic colorectal cancer [ICD-11: 2B91.Z]	N.A.	MacroGenics	[1]

Clinical Trial Information of This SBP
NCT02248805	Click to show the Detail
Indication	Relapsed or Refractory Metastatic Colorectal Carcinoma
Phase	Phase I
Title	A Phase I, First-in-Human, Open Label, Dose Escalation Study of?MGD007, A Humanized gpA33 x CD3 DART? Protein in Patients With Relapsed/Refractory Metastatic Colorectal Carcinoma
Status	Completed
Sponsor	MacroGenics
NCT03531632	Click to show the Detail
Indication	Relapsed or Refractory Metastatic Colorectal Carcinoma
Phase	Phase I; Phase II
Title	A Phase Ib/2, Open Label, Dose Escalation Study of?MGD007, a Humanized gpA33 CD3 DART? Protein in Combination With MGA012, an Anti-PD-1 Antibody, in Patients With Relapsed or Refractory Metastatic Colorectal Carcinoma
Status	Active, not recruiting
Sponsor	MacroGenics

References

1

MacroGenics. Product Development Pipeline. 2021.