Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP000130) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
DARPin anti-ERBB1 PSC106
|
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| Synonyms |
DARPin PSC106
|
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| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Highest Status | Research | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS027 | [1] | ||||
| Scaffold Name | DARPin | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Alpha-Helices + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | Modulator | Cancers [ICD-11: 2D4Z] | Kd: 0.08 nM | ImmunoGen; Molecular Partners | [1] | |
| Epidermal growth factor receptor | Modulator | Cancers [ICD-11: 2D4Z] | Kd: 2.3 nM | ImmunoGen; Molecular Partners | [1] | |