General Information of Synthetic Binding Protein (SBP) (ID: SBP000115)
SBP Name
DARPin anti-CASP-5 D5.15
Synonyms
DARPin D5.15
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Ribosome display
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS027
Scaffold Info
[1]
Scaffold Name DARPin
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Caspase-5
BTS Info
Binder Research tool Kd: 11 nM University of Zurich [1]
References
1 Specific targeting of human caspases using designed ankyrin repeat proteins. Biol Chem. 2014 Oct;395(10):1243-52.