Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP000096) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Anticalin anti-Abeta40 H1GA
|
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| Synonyms |
Anticalin H1GA
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| Molecular Weight | 20.2 kDa | |||||
| Thermal Denaturation TEMP | 66.2 ℃ | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Escherichia coli | |||||
| Selection Method | Phage display | |||||
| Highest Status | Research | |||||
| PDB ID | 4MVL | |||||
| Sequence Length | 178 | |||||
| SBP Sequence |
>Anticalin anti-Abeta40 H1GA
QDSTSDLIPAPPLSKVPLQQNFQDNQFHGKWYVVGAAGNVLLREDKDPLKMYATIYELKE DKSYNVTSVGFDDKKCLYKIRTFVPGsQPGEFTLGRIKSEPGGTSWLVRVVSTNYNQHAM VFFKEVAQNRETFNITLYGRTKELTSELKENFIRFSKSLGLPENHIVFPVPIDQCIDG |
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| 3D Structure | ||||||
| Experimentally Validated Structure | ||||||
| Click to Save PDB File | ||||||
| Template Name | Lipocalin 2 (Lcn2) | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS011 | [1] | ||||
| Scaffold Name | Anticalin | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | One Alpha-Helix + Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Amyloid-beta A4 protein | Inhibitor | Alzheimer disease [ICD-11: 8A20] | Kd: 12 nM | Technical University of Munich | [1] | |