General Information of Synthetic Binding Protein (SBP) (ID: SBP000065)
SBP Name
Anticalin anti-HGFR PRS-110
Synonyms
Anticalin PRS-110
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS011
Scaffold Info
[1] , [2]
Scaffold Name Anticalin
Scaffold Class Non-Antibody
Fold Type One Alpha-Helix + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Hepatocyte growth factor receptor
BTS Info
Antagonist Research tool Kd: 0.6 nM Pieris AG [1] , [2]
References
1 Recent advances in the development of novel protein scaffolds based therapeutics. Int J Biol Macromol. 2017 Sep;102:630-641.
2 In vivo visualization of MET tumor expression and anticalin biodistribution with the MET-specific anticalin 89Zr-PRS-110 PET tracer. J Nucl Med. 2014 Apr;55(4):665-71.