Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000063)
SBP Name
Anticalin PRS-060
Synonyms
PRS060; AZD 1402
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Phase II
Protein Scaffold Information of This SBP
Scaffold ID PS011
Scaffold Info
[1] , []
Scaffold Name Anticalin
Scaffold Class Non-Antibody
Fold Type One Alpha-Helix + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Interleukin-4 receptor subunit alpha
BTS Info
Antagonist Asthma [ICD-11: CA23] N.A. Pieris AG; AstraZeneca [1] , []
Clinical Trial Information of This SBP
NCT03384290 Click to show the Detail
Indication Healthy
Phase Phase I
Title A Dose Escalating Single Blind Study to Assess the Safety, Tolerability and Pharmacokinetics of a Single Dose of?PRS-060?Administered by Oral Inhalation or IV Infusion in Healthy Subjects
Status Completed
Sponsor Pieris Australia Pty Ltd
NCT03574805 Click to show the Detail
Indication Mild Asthma
Phase Phase I
Title A Dose-Escalating, Single-Blind Study to Assess the Safety, Tolerability, and Pharmacokinetics of Multiple Doses of?PRS-060?Administered by Oral Inhalation in Subjects With Mild Asthma
Status Recruiting
Sponsor Pieris Australia Pty Ltd
NCT03921268 Click to show the Detail
Indication Healthy
Phase Phase I
Title A Randomized Open Label, 3-period, 3-treatment, Crossover Study to Assess the Effect of Inhalation Device and Formulation on Pharmacokinetics Following a Single Inhaled Dose of AZD1402 in Healthy Subjects
Status Completed
Sponsor AstraZeneca
References
1 Recent advances in the development of novel protein scaffolds based therapeutics. Int J Biol Macromol. 2017 Sep;102:630-641.