Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00603) | ||||||
|---|---|---|---|---|---|---|
| BTS Name |
Shiga-like toxin 2 subunit A
|
|||||
| Synonyms |
EC:3.2.2.22; SLT-2 A subunit; SLT-2a; SLT-IIa; Verocytotoxin 2 subunit A; Verotoxin 2 subunit A; rRNA N-glycosidase 2
|
|||||
| BTS Type |
Protein
|
|||||
| Family |
ribosome-inactivating protein family
|
|||||
| Gene Name |
stxA2
|
|||||
| Organism |
Escherichia phage 933W (Bacteriophage 933W)
|
|||||
| Function |
The A subunit is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits. After endocytosis, the A subunit is cleaved by furin in two fragments, A1 and A2: A1 is the catalytically active fragment, and A2 is essential for holotoxin assembly with the B subunits.
|
|||||
| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MKCILFKWVLCLLLGFSSVSYSREFTIDFSTQQSYVSSLNSIRTEISTPLEHISQGTTSV
SVINHTPPGSYFAVDIRGLDVYQARFDHLRLIIEQNNLYVAGFVNTATNTFYRFSDFTHI SVPGVTTVSMTTDSSYTTLQRVAALERSGMQISRHSLVSSYLALMEFSGNTMTRDASRAV LRFVTVTAEALRFRQIQREFRQALSETAPVYTMTPGDVDLTLNWGRISNVLPEYRGEDGV RVGRISFNNISAILGTVAVILNCHHQGARSVRAVNEESQPECQITGDRPVIKINNTLWES NTAAAFLNRKSQFLYTTGK |
|||||
| Sequence Length |
319
|
|||||
| Synthetic Binding Protein (SBP) Targeting This BTS |
|---|
| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| DARPin anti-Stx2a #3 | Research | Inhibitor | Kd: 8.83 nM | Shiga toxin-producing E. coli infection (STEC infection) [ICD-11: XN108] | [1] | |
| DARPin anti-Stx2a 10B | Research | Inhibitor | Kd: 3450 nM | Shiga toxin-producing E. coli infection (STEC infection) [ICD-11: XN108] | [1] | |
| DARPin anti-Stx2a SHT | Research | Inhibitor | Kd: 27 nM | Shiga toxin-producing E. coli infection (STEC infection) [ICD-11: XN108] | [1] | |