General Information of Binding Target of SBP (BTS) (ID: ST00602)
BTS Name
CD70 antigen
Synonyms
CD27 ligand;CD27-L; Tumor necrosis factor ligand superfamily member 7; CD Antigen CD70
BTS Type
Protein
Family
tumor necrosis factor family
Gene Name
CD70
Organism
Homo sapiens (Human)
Function
Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells).; The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells
UniProt ID
P32970
UniProt Entry
CD70_HUMAN
PFam
PF00229
Gene ID
970
Sequence
MPEEGSGCSVRRRPYGCVLRAALVPLVAGLVICLVVCIQRFAQAQQQLPLESLGWDVAEL
QLNHTGPQQDPRLYWQGGPALGRSFLHGPELDKGQLRIHRDGIYMVHIQVTLAICSSTTA
SRHHPTTLAVGICSPASRSISLLRLSFHQGCTIASQRLTPLARGDTLCTNLTGTLLPSRN
TDETFFGVQWVRP
Sequence Length
193
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Nanobody anti-CD70 Nb-2B3 Research blocker Kd: 52.9 nM Cancers [ICD-11: 2D4Z]
SBP Info
[1]
Nanobody anti-CD70 Nb-3B6 Research blocker Kd: 51.5 nM Cancers [ICD-11: 2D4Z]
SBP Info
[1]
References
1 Identification and characterization of blocking nanobodies against human CD70. Acta Biochim Biophys Sin (Shanghai). 2022 Oct 25;54(10):1518-1527.