Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00595) | ||||||
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| BTS Name |
Neurotensin receptor type 1
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| Synonyms |
NT-R-1; NTR1; High-affinity levocabastine-insensitive neurotensin receptor; NTRH
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| BTS Type |
Protein
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| Family |
G-protein coupled receptor 1 family;
Neurotensin receptor subfamily; NTSR1 sub-subfamily |
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| Gene Name |
NTSR1
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| Organism |
Homo sapiens (Human)
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| Function |
G-protein coupled receptor for the tridecapeptide neurotensin (NTS).; Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDI
YSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAM PVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLM SRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVN TFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRH GVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTIN PILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY |
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| Sequence Length |
418
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
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| Macrocyclic peptide anti-NTS2 CR-01-64 | Research | Inhibitor | Ki: 871 nM | Tools for analgesic effect | [1] | |