General Information of Binding Target of SBP (BTS) (ID: ST00561)
BTS Name
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Synonyms
G gamma-I
BTS Type
Protein
Family
G protein gamma family
Gene Name
GNG2
Organism
Bos taurus (Bovine)
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
UniProt ID
P63212
UniProt Entry
GBG2_BOVIN
PFam
PF00631
Gene ID
281203
Sequence
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
FREKKFFCAIL
Sequence Length
71
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Nanobody anti-Gs Nb35 Research Binder N.A. Research tool
SBP Info
[1], [2]
References
1 Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell. 2021 Feb 18;184(4):931-942.e18.
2 Crystal structure of the 2 adrenergic receptor-Gs protein complex. Nature. 2011 Jul 19;477(7366):549-55.