Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00560)
BTS Name
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Synonyms
Transducin beta chain 1
BTS Type
Protein
Family
WD repeat G protein beta family
Gene Name
Gnb1
Organism
Rattus norvegicus (Rat)
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
UniProt ID
P54311
UniProt Entry
GBB1_RAT
PFam
PF00400
Gene ID
24400
Sequence
MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF
TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL
KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Sequence Length
340
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Nanobody anti-Gs Nb35 Research Binder N.A. Research tool
SBP Info
 		[1], [2]
References
1 Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell. 2021 Feb 18;184(4):931-942.e18.
2 Crystal structure of the 2 adrenergic receptor-Gs protein complex. Nature. 2011 Jul 19;477(7366):549-55.