Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00559)
BTS Name
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Synonyms
Adenylate cyclase-stimulating G alpha protein
BTS Type
Protein
Family
G-alpha family. G(s) subfamily
Gene Name
GNAS; GNAS1; GSP
Organism
Homo sapiens (Human)
Function
Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2.
UniProt ID
P63092
UniProt Entry
GNAS2_HUMAN
PFam
PF00503
Gene ID
2778
Sequence
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQM
RILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELA
NPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLD
KIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFND
VTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEK
VLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCY
PHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
Sequence Length
394
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Nanobody anti-Gs Nb35 Research Binder N.A. Research tool
SBP Info
 		[1], [2]
References
1 Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell. 2021 Feb 18;184(4):931-942.e18.
2 Crystal structure of the 2 adrenergic receptor-Gs protein complex. Nature. 2011 Jul 19;477(7366):549-55.